GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation
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چکیده
منابع مشابه
Regulation of self-renewing neural progenitors by FGF/ERK signaling controls formation of the inferior colliculus.
The embryonic tectum displays an anteroposterior gradient in development and produces the superior colliculus and inferior colliculus. Studies suggest that partition of the tectum is controlled by different strengths and durations of FGF signals originated from the so-called isthmic organizer at the mid/hindbrain junction; however, the underlying mechanism is unclear. We show that deleting Ptpn...
متن کاملThe hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors.
How epithelial progenitor cells integrate local signals to balance expansion with differentiation during organogenesis is still little understood. Here, we provide evidence that the Hippo pathway effector Yap is a key regulator of this process in the developing lung. We show that when epithelial tubules are forming and branching, a nucleocytoplasmic shift in Yap localization marks the boundary ...
متن کاملSelf-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells
Background & Aims Three-dimensional organoid culture has fundamentally changed the in vitro study of intestinal biology enabling novel assays; however, its use is limited because of an inaccessible luminal compartment and challenges to data gathering in a three-dimensional hydrogel matrix. Long-lived, self-renewing 2-dimensional (2-D) tissue cultured from primary colon cells has not been accomp...
متن کاملbeta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors.
In the embryonic kidney, progenitors in the metanephric mesenchyme differentiate into specialized renal epithelia in a defined sequence characterized by the formation of cellular aggregates, conversion into polarized epithelia and segmentation along a proximal-distal axis. This sequence is reiterated throughout renal development to generate nephrons. Here, we identify global transcriptional pro...
متن کامل-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors
INTRODUCTION Development of the metanephric kidney is initiated when the ureteric bud enters the metanephric mesenchyme and induces mesenchymal progenitors to differentiate into renal epithelia. Epithelialization of the metanephric mesenchyme develops in a sequence that is currently defined by morphological criteria and by the expression of signature molecules (Dressler, 2006). Initially, metan...
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ژورنال
عنوان ژورنال: JCI Insight
سال: 2019
ISSN: 2379-3708
DOI: 10.1172/jci.insight.122947